Clinical observational studies are a type of clinical research that aims to understand causes of illnesses, study trends in how conditions manifest, describe and explain outcomes, and find methods to diagnose and monitor disease in people. Often, “healthy” participants are recruited to provide a comparison to participants with the condition being studied.

The knowledge learned from these studies is used to identify interventions, techniques, technologies, tools, and best practices that enhance health care.

Within the Department of Physical Medicine and Rehabilitation, our team of clinician-scientists investigate imaging biomarkers of recovery after stroke, devices to measure muscle health at the bedside, and factors affecting outcomes after hip fracture, to name just a few. Please see the table below for more details, including an overview of ongoing studies, contact information, and links to study details and investigator profiles.

Study NameSponsor / Funding AgencyPrincipal InvestigatorMU Contact
Accurate and rapid assessment of sarcopenia in older adults
through electrical impedance myography: The MUSCLE Health Study
National Institute on AgingW. David Arnold, MDArnold Lab Clinical Research Staff, contactarnoldlab@missouri.edu
Tonic GABAergic inhibition during the repair phase of human strokeAmerican Heart AssociationCarmen Cirstea, MD, PhD, FAHACarmen Cirstea, Assistant Research Professor, cirsteac@health.missouri.edu
Autonomic cardiac function in subacute spinal cord injury: a quantitative study in real-world settingsUM Spinal Cord Injuries/ Disease Research Disease ProgramCarmen Cirstea, MD, PhD, FAHACarmen Cirstea, Assistant Research Professor, cirsteac@health.missouri.edu
Neural Mechanisms of Motor Fatigability in Myotonic Dystrophy Type 1Myotonic Dystrophy FoundationKristina M. Kelly, PT, DPT, MS, EdM, NCS, CPT, PESKristina Kelly, Assistant Research Professor, kristina.kelly@health.missouri.edu
Early weight-bearing effects on geriatric hip fracture recovery - a quantitative studyHealthSouthChrissa McClellan, MDChrissa McClellan, Associate Professor, mcclellancl@health.missouri.edu