M. Frederick Hawthorne, PhD

Hawthorne

Radiology

Director, International Institute of Nano and Molecular Medicine
Curators' Distinguished Professor of Chemistry and Radiology, University of Missouri
University Professor of Chemistry Emeritus, University of California

573-882-7016

Academic Information

Director, International Institute of Nano and Molecular Medicine
Curators' Distinguished Professor of Chemistry and Radiology, University of Missouri
University Professor of Chemistry Emeritus, University of California
P. 573-882-7016

Research Interests

I am interested in exploratory inorganic and organometallic chemical syntheses, reaction mechanisms, homogeneous catalysis, cluster species. Bioinorganic chemistry interests include liposome syntheses with boron-10 for neutron capture therapy of cancer, design and synthesis of new radionuclide complexes for antibody conjugation leading to cancer diagnosis and therapy, design and synthesis of mercurocarborand species suitable for host-guest interactions, and synthesis of supramolecular molecules (rods, rings and chains) based upon carborane skeletons and suitable for use as components in nanodevices and biomolecules.

Areas of Expertise

  • Boron Chemistry

Education & Training

Medical School

Pomona College, Claremont, CA; University of California, Los Angeles, CA; Iowa State University, Ames, IA

Awards & Honors

  • 1963 - Awarded Alfred P. Sloan Research Fellowship
  • 1968 - Chancellor's Award for Research, the University of California, Riverside
  • 1969 - Corn Products Lecturer, Penn State University
  • 1969 - Wooley Lecturer, Georgia institution of Technology
  • 1969 - Minnesota Mining and Manufacturing Lecturer, University of Minnesota
  • 1972 - Herbert Newby McCoy Award for Contributions to Chemistry, University of California, Los Angeles
  • 1973 - American Chemical Society Award in Inorganic Chemistry
  • 1973 - Dupont Lecturer, University of South Carolina
  • 1973 - Distinguished Visiting Professor, Harvard University
  • 1973 - Elected to U.S. National Academy of Sciences
  • 1974 - Venable Lecturer, University of North Carolina
  • 1974 - Degree of Doctor of Science honoris causa, Pomona College
  • 1974 - Reilly Lecturer, Notre Dame
  • 1974 - Distinguished Scientist Lecturer, Michigan State University
  • 1974 - Distinguished Scientist Lecturer, North Carolina State University
  • 1975 - Elected to American Academy of Arts and Sciences
  • 1975 - Visiting Professor in Chemistry, University of Texas at Austin
  • 1975 - Frontiers in Chemistry Lecturer, Wayne State University
  • 1976 - Elected to Cosmos Club, Washington, D.C.
  • 1978 - Nebraska Section of the American Chemical Society Award
  • 1980 - Elected Fellow of the American Association for the Advancement of Science
  • 1984 - Frontiers in Chemical Research Colloquium, Texas A & M University
  • 1985 - Distinguished Scientist Lecturer, Purdue University
  • 1986 - Meritorious Civilian Service Medal, Department of the U.S. Air Force
  • 1986 - Tolman Medal Award of the Southern California Section of the American Chemical Society
  • 1986 - Fellow of the Japan Society for the Promotion of Science
  • 1986 - Castle Chemistry Lecturer, University of South Florida
  • 1988 - First Recipient of the Boron USA (BUSA) Award for Distinguished Achievements in Boron Chemistry
  • 1988 - American Chemical Society Award for Distinguished Service in the Advancement of Inorganic Chemistry
  • 1989 - National Science Foundation Lecturer, Auburn University
  • 1989 - McElvain Lecturer, University of Wisconsin
  • 1990 - Alexander von Humboldt Award for Senior U.S. Scientists
  • 1990 - Distinguished Visiting Professor, The Ohio State University
  • 1991 - John C. Bailar Medal for Achievement in Inorganic Chemistry
  • 1992 - Gooch-Stephens Lecturer, Baylor University
  • 1992 - Degree of Doctor of Philosophy honoris causa, Uppsala University
  • 1993 - Polyhedron Medal and Prize for Creativity in Inorganic and Organometallic Chemistry (Sir Geoffrey Wilkinson Medal)
  • 1994 - Chemical Pioneer Award of the American institution of Chemists
  • 1994 - Williard Gibbs Medal of the Chicago Section of the American Chemical Society
  • 1994 - President Elect of the International Society for Neutron Capture Therapy
  • 1995 - Robert A. Welch Foundation Lecturer
  • 1995 - Distinguished Inorganic Summer Lecturer, Northwestern University
  • 1995 - Elected to Göttingen Academy of Sciences (Corresponding Member)
  • 1995 - Faculty Research Lecturer, The University of California, Los Angeles
  • 1996 - President of the International Society for Neutron Capture Therapy
  • 1996 - Boomer Lecturer, The University of Alberta, Edmonton, Alberta, Canada
  • 1996 - First Recipient of the Award for Polyhedral Borane Chemistry, presented by the IMEBORON International Committee on Boron Chemistry
  • 1996 - Center of Academic and Research Excellence, Certificate of Appreciation for Excellent Mentorship of C.A.R.E. Students
  • 1997 - National Academy of Sciences Award in Chemical Sciences
  • 1997 - Seaborg Medal, UCLA Association of Chemists and Biochemists
  • 1997 - Swift Lecturer, California institution of Technology
  • 1997 - Waite Philip Fishel Lecturer, Vanderbilt University
  • 1998 - Haines-Morris Lecturer, University of Tennessee
  • 1998 - Lyle Dawson Lecturer, University of Kentucky
  • 1998 - Invited Speaker, Frontiers in Chemistry Meeting Celebrating the 50th Anniversary of the State of Israel, Israeli Academy of Sciences
  • 1998 - Named University Professor by the Regents of the University of California
  • 1998 - Centenary Lecturer, The Royal Society of Chemistry (London)
  • 1998 - Presiding Officer, The Eighth International Symposium on Neutron Capture Therapy for Cancer, La Jolla, California
  • 2001 - Basolo Medal of the Chicago Section of the American Chemical Society
  • 2001 - Coates Lecturer, University of Wyoming
  • 2001 - Distinguished Visiting Scholar, Chinese University of Hong Kong
  • 2003 - King Faisal International Prize for Science (co-winner)
  • 2004 - Monie A. Ferst Award from the Georgia institution of Technology Chapter of the Sigma Xi Society
  • 2004 - The First Burg Lecturer Celebrating the 100th Birthday of Anton Burg, University of Southern California, Los Angeles, California.
  • 2007 - Lloyd L. Thomas Memorial Lecturer, College of Arts and Sciences, University of Missouri-Columbia.
  • 2007 - Alan Davison Lecturer, Massachusetts institution of Technology
  • 2008 - Hans B. Jonassen Lecture, Tulane University
  • 2009 - American Chemical Society Priestley Medalist
  • 2009 - Appointed a Fellow of the American Chemical Society
  • 2009 - Senate of the State of Missouri Resolution of Appreciation for Scientific Achievements, April 14, 2009 (Senate Resolution 795 Offered by Senator Kurt Schaefer)
  • 2010 - Curators’ Distinguished Professor, University of Missouri
  • 2011 - M. Frederick Hawthorne Lecture established, University of California, Los Angeles
  • 2012 - Pioneer Award, Boron in the Americas
  • 2013 - 2011 National Medal of Science
  • 2013 - Senate of the United States of America, Tribute read into the Congressional Record by Senator Roy Blunt of Missouri, January 31, 2013, to commemorate Hawthorne’s National Medal of Science.
  • 2013 - Senate of the State of Missouri Resolution of Appreciation for Scientific Achievements, March 7, 2013 (Senate Resolution 214 Offered by Senator Kurt Schaefer)
  • 2013 - Missouri State House of Representatives Resolution of Appreciation for Scientific Achievements, March 7, 2013 (House Resolution 646 Offered by Representative Chris Kelly)
  • 2013 - MU Tap Day inductee: Omicron Delta Kappa
  • 2015 - Inventor Member, National Academy of Inventors (NAI), Mizzou Chapter
  • 2016 - Fellow of the National Academy of Inventors

Publications

  • Lalit Goswami, Lixin Ma, Shatadru Chakravarty, Quanyu Cai, Satish Jalisatgi, M. Frederick Hawthorne.  “Discrete Nanomolecular Polyhedral Borane Scaffold Supporting Multiple Gadolinium(III) Complexes as a High Performance MRI Contrast Agent.”  Inorg. Chem.  2013, 52 (4), 1694-1700.
  • Lalit Goswami, Lixin Ma, Quanyu Cai, Saurav Sarma, Satish Jalisatgi, M. Frederick Hawthorne. “cRGD Peptide-Conjugated Icosahedral closo-B122- Core Carrying Multiple Gd3+ -DOTA Chelates for ανβ3 Integrin-Targeted Tumor Imaging (MRI).”  Inorg. Chem. 2013, 52, 1701-1709.
  • Kuanysh Kabytaev, Alexander V. Safronov, Thomas A. Everett, Satish S. Jalisatgi, M. Frederick Hawthorne. “B-Mercaptocarboranes: A New Synthetic Route.” European Journal of Inorganic Chemistry, 2013, 14, 2488-2491.
  • Peter J. Kueffer, Charles A. Maitz, Aslam A. Khan, Seth A. Schuster, Natalia I. Shlyakhtina, Satish S. Jalisatgi, John D. Brockman, David W. Nigg, M. Frederick Hawthorne. “Boron neutron capture therapy demonstrated in mice bearing EMT6 tumors following selective delivery of boron by rationally designed liposomes.” PNAS  vol. 110,
  • 16, 6512-6517 (2013).
  • Alexei Pushechnikov, Satish S. Jalisatgi, M. Frederick Hawthorne. “Dendritic closomers: novel spherical hybrid dendrimers.”  Chem. Commun.  2013, 49, 3579-3581.
  • M. Frederick Hawthorne. “Interview with M. Frederick Hawthorne.”  Future Medicinal Chemistry. 2013, vol. 5, no. 6, 627-632.
  • Lalit N. Goswami, Lixin Ma, Peter J. Kueffer, Satish S. Jalisatgi and M. Frederick Hawthorne. “Synthesis and Relaxivity Studies of a DOTA-based Nanomolecular Chelator Assembly Supported by an Icosahedral Closo-B122- -Core for MRI: A Click Chemistry Approach.”  Molecules 2013, 18(8), 9034-9048.
  • Oleg Bondarev, Aslam A. Khan, Xiaoyan Tu, Yulia V. Sevryugina, Satish S. Jalisatgi, M. Frederick Hawthorne. “The Synthesis of [closo-B12(OH)11NH3]- : A New Heterobifunctional Dodecaborane Scaffold for Drug Delivery Applications.  J. Am. Chem. Society, 2013, 135(35), 13204-13211.
  • Alexander Safronov, Yulia Sevryugina, Kothanda Pichaandi, Satish Jalisatgi, M. Frederick Hawthorne. “Synthesis of closo- and nido-Biscarboranes with Rigid Unsaturated Linkers as Precursors to Linear Metallacarborane-Based Molecular Rods.” Dalton Transactions. 2014, 43 (13), 4969-4977.
  • Kuanysh Z. Kabytaev, Alexander Valentinovich Safronov, Satish Jalisatgi, M. Frederick Hawthorne. “Synthesis and Reactions of B-Vinylcarboranes.”  Journal of Organometallic Chemistry. 749 (2014) 106-108.
  • Lalit N. Goswami, Aslam A. Khan, Satish S. Jalisatgi and M. Frederick Hawthorne.  “Synthesis and In Vitro Assessment of a Bifunctional Closomer Probe for Fluorine (19F) Magnetic Resonance and Optical Bimodal Cellular Imaging.”  Chem. Commun., 2014, 50 (43), 5793-5795.
  • 559. Alexander V. Safronov, Kuanysh Z. Kabytaev, Satish S. Jalisatgi, M. Frederick Hawthorne. “Novel Iodinated Carboranes: Synthesis of 8-Iodo-7,9-dicarba-nido-undecaborate Anion and 2-Iodo-1,7-dicarba-closo-dodecaborane.”  Dalton Trans., 2014,   43 (33), 12467 – 12469.
  • Alexander Safronov, Natalia Shlyakhtina, Thomas Everett, Monika VanGordon, Yulia Sevryugina, Satish Jalisatgi, M. Frederick Hawthorne. “Direct Observation of Bis(dicarbollyl)nickel Conformers in Solution by Fluorescence Spectroscopy: An Approach to Redox-Controlled Metallacarborane Molecular Motors.”  Inorg. Chem.,  2014, 53, 10045-10053.
  • Elisa M. Heber, M. Frederick Hawthorne, Peter J. Kueffer, Marcella A Garabalino, Silvia I. Thorp, Emiliano C.C. Pozzi, Andrea Monti Hughes, Charles A. Maitz, Satish S. Jalisatgi, David W. Nigg, Paula Curotto, Veronica A. Trivillin, Amanda E. Schwint. “Therapeutic Efficacy of Boron Neutron Capture Therapy Mediated by Boron-rich Liposomes for Oral Cancer in the Hamster Cheek Pouch Model.”  PNAS.  2014, 111(45), 16077-16081.
  • George R. Kracke, Yulia V. Sevryugina, Monika R. VanGordon, Peter J. Kueffer, Kuanysh Kabytaev, Satish S. Jalisatgi, M. Frederick Hawthorne. “Carborane Derived Local Anesthetics are Isomer Dependent.” ChemMedChem  2015, 10(1), 62-67.
  • Kabytaev, Kuanysh; Safronov, Alexander; Sevryugina, Yulia; Barnes, Charles; Jalisatgi, Satish; Hawthorne, M. Frederick. "Novel Synthetic Approach to Charge-Compensated Phosphonio-nido-Carboranes. Synthesis and Structural Characterization of Neutral Mono and Bis(Phosphonio) nido-ortho-Carboranes."  Inorg. Chem., 2015, 54 (8), pp 4143-4150.
  • Natalia I. Shlyakhtina, Alexander V. Safronov, Yulia V. Sevryugina, Satish S. Jalisatgi, M. Frederick Hawthorne. “Synthesis, Characterization, and Preliminary Fluorescence Study of a Mixed-ligand Bis(dicarbollyl)nickel Complex Bearing a Tryptophan-BODIPY FRET Couple.” Journal of Organometallic Chemistry. 2015. DOI: 10.1016/j.jorganchem.2015.04.035.
  • Lalit N. Goswami, Lixin Ma, Quanyu Cai, Shatadru Chakravarty, Satish S. Jalisatgi and M. Frederick Hawthorne. “Synthesis, Relaxivity and In vivo Assessment of a Multimeric Gd-DTPA Conjugate of closo-Doedecaborate Dianion as Blood Pool MRI Contrast Agent.”  Organic and Biomolecular Chemistry. 2015, 13, 8912-8918.
  • Safronov, Alexander; Tran, Doanh; Sevryugina, Yulia; Satish S. Jalisatgi, Hawthorne, M.Frederick.  "Facile Synthesis of Mixed-Ligand Bis(dicarbollyl) Complexes of Nickel."Journal of Organometallic Chemistry, 2016.  DOI: 10.1016/j.jorganchem.2016.01.002.
  • Alexander V. Safronov; Satish S. Jalisatgi; M. Frederick Hawthorne. “Synthesis of 10B-Enriched Sodium Borohydride.” Inorganic Chemistry. 2016. DOI: 10.1021/acs.inorgchem.6b01002.
  • Saurav J. Sarma; Aslam A. Khan; Lalit N. Goswami; Satish S. Jalisatgi; M. Frederick Hawthorne. “A Trimodal Closomer Drug-Delivery System Tailored with Tracing and Targeting Capabilities.” Chemistry, A European Journal. 2016. DOI: 10.1002/chem.201602413.