Eleonora S. Pagano, PhD, MSc

Eleonora S. Pagano, PhD, MSc

Pediatrics

Assistant Research Professor of Pediatrics

573-882-4893

Academic Information

Assistant Research Professor of Pediatrics

Office

1 Hospital Dr
Room M148 and MA103
Columbia, MO 65201
United States

P. 573-882-4893

Research Interests

  • Adipose tissue, obesity and related pathologies.
  • Circadian metabolic disruption and pharmacological prevention.
  • Nutrition, obesity and aging.
  • Women's health and aging.
  • Premature Ovarian Failure & Insufficiency (POF & POI).
  • Cancer and obesity interaction: Intermittent Hypoxia in Melanoma

Areas of Expertise

  • Adipocyte proliferation and differentiation.
  • Growth factor receptor signaling in normal physiology and cancer.
  • Obesity and Metabolic Syndrome circadian disruption. Chronopathology/ Chronotherapy.
  • Physiological HRT.

Education & Training

Degrees

2005 PhD in Biological Chemistry, University of Buenos Aires
1999 Master in Biological Science, University of Buenos Aires

Awards & Honors

  • 2022 - to date Assistant Research Professor at the Child Health Department, School of Medicine, University of Missouri.
  • 2009 - to date Assistant Professor at the National Council for Scientific and Technological Research (on leave from November 2022).
  • 2006 - 2009 CONICET Posdoctoral fellowship award.
  • 2004 Asociación Dante Alighieri Perfectioning fellowship: “Lingua e Cultura Italiana (Italian Language and Culture)”. Culture Secretary of the city of Trieste, Italy.
  • 2000 - 2005 CONICET PhD fellowship award.
  • 2000 External Internship. Molecular Pharmacology and Pathology Lab. Consorzio Mario Negri Sud. Santa Maria Imbaro, Chieti, Abruzzo, Italy.
  • 1999 - 2000 National Agency for the Scientific and Technologic Promotion (ANPCyT) Initiation fellowship.
  • 1998 - 1999 Fundación Sales student fellowship award.
  • 1996 - 1997 Internship (Trainee period): Reproduction Lab.

Publications

  • Pagano ES, Peña J and Spinedi E.
    "Efficacy of Co-Adjuvant Melatonin and Resveratrol Chronotherapy for Pregnancy Achievement in Premature Ovarian Failure (POF).”
    Ann Clin Case Rep. 2023;8(1):2454. DOI: 10.25107/2474-1655.2454 Epub 2023 Aug 15
  • Martino Adami PV, Galeano P, Wallinger ML, Quijano C, Rabossi A, Pagano ES, Olivar N, Reyes Toso C, Cardinali D, Brusco LI, Do Carmo S, Radi R, Gevorkian G, Castaño EM, Cuello AC, Morelli L.
    “Worsening of memory deficit induced by energy-dense diet in a rat model of early-Alzheimer's disease is associated to neurotoxic Aβ species and independent of neuroinflammation”.
    Biochim Biophys Acta Mol Basis Dis.2017 Mar;1863(3):731-743. doi: 10.1016/j.bbadis.2016.12.014. Epub 2016 Dec 27.
  • Pagano ES, Spinedi E, Gagliardino JJ.
    “White Adipose Tissue and Circadian Rhythm Dysfunctions in Obesity Pathogenesis & Available Therapies”.
    Neuroendocrinology. 2017;104(4):347-363. doi: 10.1159/000453317. Epub 2016 Nov 16.  

Peer Reviewed Conference Proceedings

Oral Presentations

International

  • International Conference on Proteomics and Molecular Medicine 2020, Zurich, Switzerland “Endocrine-metabolic white adipose tissue dysfunction: a novel sight for cardiovascular disease diagnosis and treatment”. S. Spinedi, J.J. Gagliardino, Eleonora S. Pagano. Virtual
  • European Congress of Obesity ECO 2019, Glasgow, Scotland, UK “Melatonin exerts benefic effects on the rat model of Metabolic Syndrome and on the normal rat.” Eleonora S. Pagano, Eduardo Spinedi, Daniel P. Cardinali and Ana Genaro. Poster presentation. Obes Facts 2019;12:1–298 doi.org/10.1159/000497797 eISSN:1662-4033
  • International Conference on Obesity & Weight Management, Philadelphia, USA, 2012. “Melatonin in Obesity: Possible therapeutic role.” Eleonora S. Pagano, Pablo A. Scacchi, Eduardo Spinedi and Daniel P. Cardinali. J Obes Wt Loss Ther /S1: 2165-7904-S1.008-9/Special Issue 2012 doi: 10.4172/2165-7904.S1.006.
  • FASEB Summer Research Conference on Growth Factor Receptor Tyrosine Kinases in Mitogenesis, Morphogenesis and Tumorigenesis, Snowmass, Colorado, USA. 2001. Eleonora Pagano and Juan Carlos Calvo. “ErbB2 expression in Swiss 3T3L1 fibroblasts”. Poster selected to be presented at the Young Investigator Mini-Symposium.

Institutional

  • Pagano ES
    “Losing weight with the clock? Therapeutical possibilities for Melatonin in the prevention of Obesity and Metabolic Syndrome”
    Therapeutical Center Dr Ravenna, 2019
  • Pagano ES
    “Melatonin in Obesity and Metabolic Syndrome: Prevention possibilities”
    BIOMED 2019
  • Pagano ES
    “Genes-Nutrition-Obesity ¿Can we stop the new pandemic?
    University World EXPO-UCA, 2018
  • Pagano ES
    “Metabolic Syndrome and Obesity: the new XXI century pandemic. What´s Melatonin got to do with it?”
    CENEXA, La Plata, 2013

National

  • Pagano E et al. “Regulation of CFTR expression by high dosis of IL-1 beta in CaCo2 cell line would be mediated by JNK activity”.
    LV Annual Meeting of Argentine Society of Clinical Research, Mar del Plata, Argentina. Medicina 70 (Supl. II) 2010.
  • Pagano ES and Calvo JC.
    “Tyrosine kinase receptors: a new possibility in adipocytic differentiation.”
    XLVII Annual Meeting of Argentine Society of Clinical Research, Mar del Plata, Argentina. Medicina 2002, Vol 62, N° 5.
  • Pagano ES and Calvo JC.
    “Modulation of EGFR and erbB2 expression and activation in Swiss 3T3-L1 fibroblasts”.
    Scientific Seminars of Argentine Society of Biology (SAB). Buenos Aires 7 December 2001. Biocell 2002, Vol 26, Nº 2.
  • Pagano ES and Calvo JC.
    “erbB-1 (EGFR) and erbB-2 expression regulation in preadipocytes 3T3-L1 cell line”.
    XLVI Annual Meeting of Argentine Society of Clinical Research, Mar del Plata, Argentina. Medicina 2001, Vol 61, N° 5/2.

Poster and Abstract Presentations

  • Pagano ES, Varela I, Bertorello I, Padin AM, Spinedi E; Genaro A.
    “Melatonin exerts benefic effects on normal and metabolic syndrome rats.”
    1ra Reunión Conjunta 5ta RiCIFA 50va Reunión Anual SAFE, Ciudad de la Punta, San Luis; Argentina. 2018.
  • Wallinger M; Linares LM, Reyes MP, Zuccarella V, Pagano ES; Cardinali DP; Reyes Toso C.
    “High fructose-high fat diets modify body composition in rats, but not body mass.”
    LVI Annual Meeting of Argentine Society of Clinical Research, Buenos Aires, 2016.
  • Ávila MN, Santiago CF, Scacchi Bernasconi P, Trigila AP, Cardinali DP y Pagano ES.
    “Lipid Peroxidation of adipose tissue presents an oscilatory profile over which melatonin has a beneficial impact on rats with Metabolic Syndrome.”
    LIV Annual Meeting of Argentine Society of Clinical Research, Mar del Plata, Argentina. 2014.
  • Ávila MN, Scacchi Bernasconi P, Scacchi P, Cardinali DP; Pagano ES.
    “Melatonin administration diminishes lipid peroxidation in the adipose tissue of the rat with Metabolic Syndrome.”
    LVIII Annual Meeting of Argentine Society of Clinical Research, Mar del Plata, Argentina. 2013. Medicina 73 (Supl III) 2013.
  • Zubiría MG; Pagano ES; Giovambattista A; Scacchi PA; Spinedi EJ; Cardinali DP.
    “BEnefitial effect of Melatonin in the phenotype of an Experimental Metabolic Syndrome, role of abdominal adipose tissue”.
    LVII Annual Meeting of Argentine Society of Clinical Research, Mar del Plata, Argentina. 2012. Medicina 72 (Supl II) 2012.
  • Pagano ES; Jiménez-Ortega V; Cano Barquilla P; Fernández-Mateos P; Esquifino AI; Cardinali DP.
    “Melatonin administration diminishes prolactin synthesis in the rat adenohypophysis: redox state and circadian clock mechanisms."
    LVII Annual Meeting of Argentine Society of Clinical Research, Mar del Plata, Argentina. 2012. Medicina 72 (Supl II) 2012.

Scientific Societies Memberships

  • SAFE (Argentine Society of Experimental Pharmacology): since 2018.
  • SAIC (Argentine Society of Clinical Investigation): since 2009.

Languages

  • English
  • Italian
  • Spanish
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