MU Joins Nationwide Clinical Study to Test Medications for Mild-to-Moderate COVID-19

covid-19 cell dying illustration
Participants age 30 or older with COVID-19 symptoms and a positive test are eligible to join nationwide clinical study.

The University of Missouri School of Medicine Department of Emergency Medicine has joined a nationwide study to evaluate repurposed medications in the search for effective, safe treatments for mild-to-moderate COVID-19.

Repurposed medications are those already approved by the U.S. Food and Drug Administration for other indications.

Matthew Robinson, MD
Matthew Robinson, MD

“We are very pleased to be taking part in this important research project,” said Matthew Robinson, MD, principal investigator and chair for the School of Medicine’s Department of Emergency Medicine. “There currently are no approved prescription medications that can be given easily at home to treat mild-to-moderate COVID early in its course to prevent worsening of symptoms and reduce the need for hospitalization.”

ACTIV-6, “The Randomized Trial to Evaluate Efficacy of Repurposed Medications,” is a nationwide double-blind study expected to enroll nearly 15,000 participants from across the United States through its website,, and call center, 833-385-1880.

The study recently expanded its testing platform to evaluate three repurposed medications in the search for effective, safe treatments for mild-to-moderate COVID-19. Web and phone-based enrollment allows people anywhere in the United States diagnosed with COVID-19 as outpatients to help test potential COVID-19 treatments without leaving home.

The study is now testing these repurposed medications:

  • Fluticasone, an inhaled steroid commonly prescribed for asthma and chronic obstructive pulmonary disease;
  • Fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), often prescribed for depression; and
  • Ivermectin, used to treat parasitic infections

“We know the need for outpatient treatment will continue to grow as we see more cases, so this is a vital public health need,” Robinson said.

To be eligible, participants must be 30 years old or older, have had a positive COVID-19 test within the past 10 days, and have at least two symptoms of the illness for seven days or less. Symptoms include fatigue, difficulty breathing, fever, cough, nausea, vomiting, diarrhea, body aches, chills, headache, sore throat, nasal symptoms, and/or new loss of sense of taste or smell.