Sudhanshu Raikwar, BVSc & AH, MVSc, PhD

Neurology

Assistant Research Professor

Academic Information

Assistant Research Professor

Education & Training

Post-Graduate School

National Institute of Immunology, India

Awards & Honors

  • 2018 Poster Judge, University of Missouri Life Sciences Research Week
  • 2017 Poster Judge, University of Missouri Life Sciences Research Week
  • 2016 Invited Speaker, Department of Vet. Med. & Surgery, University of Missouri, Columbia, MO
  • 2015  Invited Speaker, Department of Pharmacology, University of Illinois, Chicago
  • 2012  Invited Speaker, Oklahoma Medical Research Foundation, Oklahoma City
  • 2012  Editorial Board Member, Journal of Bioscience and Medicine, BioMed Central
  • 2012 Ad hoc Reviewer, Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy
  • 2011 Ad hoc Reviewer, American Journal of Transplantation (4 manuscripts)
  • 2011 Ad hoc Reviewer, Journal of Cellular Physiology (3 manuscripts)
  • 2011 Board Member, Advisory Editorial Board, Journal of Bioscience and Medicine
  • 2011 Invited Speaker, Vistagen Therapeutics, San Francisco, CA
  • 2011 Invited Guest Speaker, Super Human Radio
  • 2010 Invited Speaker, APSC, Virginia Tech, Blacksburg, VA
  • 2010 Invited Speaker, the National Cancer Institute, Frederick, MD
  • 2010 Invited speaker, Department of Internal Medicine Grand Rounds, Roy J. & Lucille A. Carver College of Medicine, UI, Iowa City
  • 2010 Institute of Clinical and Translational Science Award, UI Health Sciences Research Week, UI, Iowa City
  • 2010 Best Translational Poster, Department of Internal Medicine Research Day, UI, Iowa City
  • 2010 Ramalingaswami Fellow, Department of Biotechnology, Govt. of India
  • 2010 Member, Editorial Board, Journal of Bioterrorism and Biodefense
  • 2010 Ad hoc Reviewer, Journal of Cellular Physiology
  • 2009 Invited Speaker, Department of Surgery, University of Arizona, Tucson
  • 2009 Young Investigator Award, American Transplant Congress, Boston, MA (Top ranking research paper selected from more than 2600 submitted) 
  • 2009               Research Highlight in “What is Hot, What is New in Basic Science,” ATC 2009, Boston, MA
  • 2009 Invited Plenary Speaker, American Transplant Congress, Boston, MA, 
  • http://atc-tea.ascendeventmedia.com/ProdCat2.aspx?id=1_3
  • 2009 UI Internal Medicine Insider, Employee Spotlight, University of Iowa, Iowa City, IA http://www.int-med.uiowa.edu/News/Newsletter/Profile.htm
  • 2009 Invited Speaker, Experimental Biology Meeting, New Orleans, LA
  • 2009 Institute of Clinical and Translational Science Award, UI Health Sciences Research Week, UI, Iowa City
  • 2007-2008 Ad hoc Reviewer, American Journal of Transplantation
  • 2007 Young Investigator Award, American Transplant Congress 2007, San Francisco
  • 2006 Young Investigator Award, World Transplant Congress 2006, Boston, MA
  • 2006 ISSCR Travel Award, fourth annual meeting of the International Society for Stem Cell Research, Toronto, Canada
  • 2004 Ad hoc Reviewer, Molecular Imaging
  • 2004 Invited Speaker, Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and University, College Station, TX
  • 2004 Invited for oral presentation at 7th annual meeting of the American Society of Gene Therapy, Minneapolis, MN
  • 2002 Invited for oral presentation at 5th annual meeting of the American Society of Gene Therapy, Boston, MA.
  • 2001 AACR-AstraZeneca Scholar-in-training Award, New Discoveries in Prostate Cancer Biology and Treatment. Naples, FL.
  • 1993-1996 Senior Research Fellowship, National Institute of Immunology, New Delhi. 
  • 1994 First position at ARS-ICAR, National Entrance Test (Animal Biotechnology).
  • ASRB-ICAR, Lecturership Eligibility Award (Animal Biotechnology).
  • 1994 CSIR-UGC, Lecturership Eligibility Award (Life Sciences).
  • 1991-1993 Junior Research Fellowship, National Institute of Immunology, New Delhi.
  • 1988-1991      Junior Research Fellowship, Indian Veterinary Research Institute, Izatnagar.

Publications

 

https://www.ncbi.nlm.nih.gov/sites/myncbi/1L_Wds6oP5SkB/bibliography/48562038/public/?sort=date&direction=ascending

 

  • Raikwar, S.P., Thangavel, R., Dubova, I., Selvakumar, G.P., Ahmed, M.E., Kempuraj, D., Iyer, S.S., Zaheer, S., and Zaheer, A. (2018): Targeted Gene Editing of Glia Maturation Factor in Microglia: A Novel Alzheimer’s Disease Therapeutic Target. Mol. Neurobiol. (In Review).
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  • Raikwar, S.P., Bhagavan, S.M., Ramaswamy, S.B., Thangavel, R., Dubova, I., Selvakumar, G.P., Ahmed, M.E., Kempuraj, D., Iyer, S.S., Zaheer, S., and Zaheer, A. (2018): Are Tanycytes the missing link between Type 2 Diabetes and Alzheimer’s Disease? Mol. Neurobiol. (In Review).
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  • Raikwar, S.P., Thangavel, R., Dubova, I., Ahmed, M.E., Selvakumar, G.P., Kempuraj, D., Iyer, S.S., Zaheer, S., and Zaheer, A. (2018): Neuro-Immuno-Gene- and Genome-Editing-Therapy for Alzheimer’s Disease: Are We There Yet? Mol. Neurobiol. (Ready for Submission to Mol. Neurobiol.).
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  • Kempuraj, D., Thangavel, R., Selvakumar, G.P., Ahmed, M.E., Zaheer, S., Raikwar, S.P., Zahoor, H., Sayeed, D., Dubova, I., Geler, G., Herr, S., Iyer, S.S. and Zaheer, A. (2018): Mast cell proteases activate astrocytes and glia-neurons and release interleukin-33 by activating p38 and ERK1/2 MAPK and NFκB. Mol. Neurodegeneration. (In Review).
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  • Selvakumar, G.P., Iyer, S.S., Kempuraj, D., Ahmed, M.E., Thangavel, R., Raikwar, S.P., Zaheer, S. and Zaheer, A. (2018): Molecular regulation of autophagy by glia maturation factor in rat dopaminergic neurons: A role for endoplasmic reticulum stress and MAPK activation. Neurobiol. Aging (In Review).
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  • Selvakumar G.P., Iyer, S.S., Kempuraj, D., Raju, M., Thangavel, R., Saeed, D., Ahmed, M.E., Zahoor, H., Raikwar, S.P., Zaheer, S., Zaheer, A. (2018): Glia Maturation Factor Dependent Inhibition of Mitochondrial PGC-1α Triggers Oxidative Stress-Mediated Apoptosis in N27 Rat Dopaminergic Neuronal Cells. Mol. Neurobiol. January 2018. https://doi.org/10.1007/s12035-018-0882-6
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  • Kempuraj, D., Thangavel, R., Selvakumar, G.P., Zaheer, S., Ahmed, M.E., Raikwar, S., Zahoor, H., Saeed, D., Natteru, P.A., Iyer, S. and Zaheer, A. (2017): Mast Cell Activation in Brain Injury, Stress and Post-Traumatic Stress Disorder and Alzheimer’s Disease Pathogenesis. Front. Neurosci. 11:703. https://doi.org/10.3389/fnins.2017.00703
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  • Thangavel, R., Bhagavan, S.M., Ramaswamy, S.B., Kempuraj, D., Zaheer, S., Raikwar, S., Ahmed, M.E., Selvakumar, G.P., Iyer, S.S. and Zaheer, A. (2017) Co-expression of glia maturation factor and apolipoprotein E4 in Alzheimer’s disease. J. Alzheimer’s Dis. 61(2):553-560.
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  • Thangavel, R., Kempuraj, D., Zaheer, S., Raikwar, S., Ahmed, M.E., Selvakumar, G.P., Iyer, S.S. and Zaheer, A. (2017): Glia Maturation Factor and Mitochondrial Uncoupling Proteins 2 and 4 Expression in the Temporal Cortex of Alzheimer’s Disease Brain. Front. Aging Neurosci. May 18:9:150:1-10.
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  • Kempuraj, D., Selvakumar, G.P., Zaheer, S., Thangavel, R., Ahmed, M.E., Raikwar, S., Iyer, S. and Zaheer, A. (2017): Cross-talk between glia, neurons and mast cells in neuroinflammation associated with Parkinson’s disease. J. Neuroimmune Pharmacol. https://doi.org/10.1007/s1148.
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  • Ahmed, M.E., Iyer, S., Thangavel, R., Kempuraj, D., Selvakumar, G.P., Raikwar, S.P., Zaheer, S. and Zaheer, A. (2017): Co-localization of glia maturation factor with NLRP3 inflammasome and autophagosome markers in human Alzheimer’s disease brain. J. Alzheimer’s Disease 60 (3) 1143-1160.
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  • Kempuraj, D., Thangavel, R., Selvakumar, G.P., Zaheer, S., Ahmed, M.E., Raikwar, S., Zahoor, H., Saeed, D., Natteru, P.A., Iyer, S. and Zaheer, A. (2017): Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration. Front. Cell. Neurosci. 11:216:1-16.
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  • Raikwar S.P., Raikwar, A.S., Chaurasia, S.S. and Mohan, R. (2016): Gene Editing for corneal disease management. World Journal of Translational Medicine 5:1: 1-13.
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  • Raikwar, S.P., Kao, C., and Gardner, T. A. (2016): Targeted Adenoviral Vectors III: Transcriptional Targeting. In: Adenoviral Vectors for Gene Therapy (Editor: David T. Curiel). Elsevier Inc. pp. 259-292.
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  • Raikwar, S.P., Kim, E. Sivitz, W.I., Allamargot, C., Thedens, D. and Zavazava, N. (2015): Human iPS cell-derived insulin producing cells form vascularized organoids under the kidney capsules of diabetic mice. PLOS ONE 10(1): e0116582. doi:10.1371/journal.pone.0116582
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  • Wang, HT. Shan, Z., Li, W., Chu, M., Yang, J., Yi, D., Zhan, J., Yuan, Z.Y., Raikwar, S., Wang, S. and Zhang C. (2015): Guidelines for assessing mouse endothelial function via ultrasound imaging: a report from the International Society of Cardiovascular Translational Research. J. Cardiovasc. Trans. Res. DOI 10.1007/s12265-015-9614-8.
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  • Raikwar, S.P.* and Zavazava, N. (2013): Differentiation and lineage commitment of murine embryonic stem cells into insulin producing cells. Methods Mol. Biol. 1029: 93-108.
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  • Raikwar, S.P.* and Zavazava, N. (2012): Pdx1 engineered ES cell-derived insulin producing cells regulate hyperglycemia in diabetic mice. Transplantation Research 18:1(1):19
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  •  Raikwar, S.P.* and Zavazava, N. (2011): Spontaneous In vivo differentiation of ES cell-derived pancreatic endoderm-like cells corrects hyperglycemia in diabetic mice. Transplantation 91 (1) 11-20. 
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  • Fabricius, D., Karacay, B., Shutt, D., Leverich, W., Schafer, B, Thedens, D., Khanna, G., Raikwar, S.P., Yang, B., Desmond, M. and O’Dorisio, M. S. (2011): Characterization of intestinal and pancreatic dysfunction in VPAC1-null mutant mice. Pancreas 40 (6) 861-871.
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  • Raikwar, S.P. and Zavazava, N. (2009): Insulin producing cells derived from embryonic stem cells: are we there yet? J. Cell. Physiol. 218 (2) 256-263. 
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  • Raikwar, S.P. and Zavazava, N. (2009): Real-time noninvasive in vivo imaging of embryonic stem cell-derived insulin producing cells. In Molecular Endocrinology: (Methods in Molecular Biology Series: Vol. 590). (Editors: Park Sarge, Ok-Kyong and Curry Jr. Thomas E.) 317-334.
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  • Chan, K-M., Raikwar, S.P. and Zavazava, N. (2007): Strategies for differentiating embryonic stem cells into insulin-producing cells and development of non-invasive imaging techniques using bioluminescence. Immunol. Res. 39:261-270.
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  • Raikwar, S.P., Mueller, T. and Zavazava, N. (2006): Strategies for developing therapeutic application of human embryonic stem cells. Physiology 21:19-28.
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  • Jimenez, J.A., Kao, C. Raikwar, S. and Gardner, T.A. (2006): Current status of anti-angiogenesis therapy for prostate cancer. Urol. Oncol. 24 (3) 260-268.
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  • Li, X., Raikwar, S.P., Liu, Y.H., Lee, S-J., Zhang, Y.P., Zhang, B., Gardner, T.A., Jeng, M.H. and Kao, C. (2006): Combination therapy of androgen-independent prostate cancer using a prostate restricted replicative adenovirus and a replication-defective adenovirus encoding human endostatin-angiostatin fusion gene. Mol. Cancer Ther. 5 (3) 676-684.
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  • Raikwar, S.P., Temm, C.J., Raikwar, N.S., Kao, C., Molitoris, B.A. and Gardner, T.A. (2005): Adenoviral vectors expressing human endostatin-angiostatin and soluble Tie2: enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model. Molecular Therapy 12 (6) 1091-100.
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  • Li X., Zhang, J., Gao, H., Vieth, E., Bae, K.H., Zhang, Y.P., Lee, S.J., Raikwar, S.P., Gardner, T.A., Hutchins, G.D., VanderPutten, D., Kao, C. and Jeng, M.H. (2005): Transcriptional targeting modalities in breast cancer gene therapy using adenovirus vectors controlled by alpha-lactalbumin promoter. Mol. Cancer Ther. 4 (12) 1850-9.  
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  • J-Q. Wang, Q-H. Zheng,, X. Fei, X. Liu, T. A. Gardner, C. Kao, S. P. Raikwar, B. E. Glick-Wilson, M. L. Sullivan, B. H. Mock and G. D. Hutchins   (2004): An improved total synthesis of PET HSV-TK gene expression imaging agent 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG). Syn. Commun. 34 (5) 897-911.
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  • Q-H. Zheng, J-Q. Wang, X. Liu, X. Fei, B. H. Mock, B. E. Glick-Wilson, M. L. Sullivan, S. P. Raikwar, T. A. Gardner, C. Kao, G. D. Hutchins (2004): An improved total synthesis of PET HSV-tk gene reporter probe 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG). Syn. Commun. 34 (4) 671-685.
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  • Q-H. Zheng, TA. Gardner, SP. Raikwar, C. Kao, K. Lee Stone, TD. Martinez, Mock, BH, Fei, X, Wang, J-Q and Hutchins, G.D. (2003): [11C] Choline as a PET biomarker for assessment of prostate cancer tumor models. Bioorg. Med. Chem. 12 (11) 2887-2893. 
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  • Raikwar, S.P., Kao, C., and Gardner, T. A. (2002): Targeted Adenoviral Vectors III: Transcriptional Targeting. In: Adenoviral Vectors for Gene Therapy (Editors: David T. Curiel and Joanne T. Douglas). Academic Press Inc. pp. 247-286.
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  • Gardner, T.A., Sloan, J.  Raikwar, S.P. and Kao, C. (2002): Prostate cancer gene therapy: Past experiences and future promise. Cancer & Metastasis Reviews 21, 137-145.
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  • Ponnazhagan, S., Weigel, K.A., Raikwar, S.P., Mukherjee, P., Yoder, M. C. and Srivastava, A. (1998): Recombinant human parvovirus B19 vectors: erythroid cell-specific delivery and expression of transduced genes. J. Virol. 72, 5224-5230.
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  • Raikwar, S.P., Malik, P., Singh, O. and Vrati, S. (1997): Recombinant adenovirus expressing cell surface anchored hCG induces bioneutralizing antibodies in rats. Gene 190, 197-202.

Research Abstracts (Selected from more than 30)

  • Raikwar, S.P., Thangavel, R., Dubova, I., Selvakumar, G.P., Ahmed, M.E., Giler, G., Kempuraj, D., Iyer, S.S., Zaheer, S., and Zaheer, A. (2018): Engineering micro-indels in glia maturation factor: a novel alzheimer’s disease therapeutic target. 21st American Society of Gene and Cell Therapy, annual meeting, May 16-19, Chicago, IL
  • Kempuraj Duraisamy, Govindhasamy Pushpavathi Selvakumar, Ramasamy Thangavel, Mohammad Ejaz Ahmed, Raikwar, S.P., Smita Zaheer, Shankar Iyer and Asgar Zaheer. Interaction of Glial Cells, Neurons and Mast Cells and Inflammatory Mediator Release in Neuroinflammation and Neurodegeneration. 47th Society for Neuroscience, annual meeting, Neuroscience 2017, November 11-15, Washington DC.
  • Govindhasamy Pushpavathi Selvakumar, Duraisamy Kempuraj, Ramasamy Thangavel, Mohammad Ejaz Ahmed, Raikwar, S.P., Smita Zaheer, Shankar S Iyer, Asgar Zaheer. Glia Maturation Factor Impairs Mitochondrial PGC-1α, Activates Redox Flux Dependent Apoptosis in Dopaminergic N27 Neuronal Cells. 47th Society for Neuroscience, annual meeting, Neuroscience 2017, November 11-15, Washington DC.
  • Mohammad Ejaz Ahmed, Ramasamy Thangavel, Kempuraj Duraisamy, Selvakumar Govindhasamy Pushpavathi, Raikwar, S.P.,  Smita Zaheer, Shankar Iyer, Asgar Zaheer. Glia Maturation Factor (GMF) Co-localizes with NLRP3 Inflammasome and Inflammatory Cytokines in the Vicinity and the Periphery of Amyloid Plaques and Neurofibrillary Tangles in Human Alzheimer’s Disease (AD) Brains. 47th Society for Neuroscience, annual meeting, Neuroscience 2017, November 11-15, Washington DC.
  • Mohammad Ejaz Ahmed, Ramasamy Thangavel, Kempuraj Duraisamy, Selvakumar Govindhasamy Pushpavathi, Raikwar, S.P.,  Smita Zaheer, Shankar Iyer, Asgar Zaheer. Enhanced glia maturation factoer (GMF) and NLRP3 inflammasome localization to the sites of amyloid plaques and neurofibrillary tangles in human Alzheimer’s disease (AD) brains. MU Life Sciences Week 2017.
  • Raikwar, S.P., Hemanth Kumar Kandikattu, Ulrich Siebenlist, Bysani Chandrasekar. A critical role of traf3ip2 in lipopolysaccharide (lps)-induced cardiac dysfunction in vivo and cardiomyocyte contractility in vitro. MU Cardiovascular Research Day 2017.
  • Mohan, R.R., Raikwar, S.P., Gupta, S., Giuliano, E.A., Fink, M., Anumanthan, G., Rieger, F.G., Sinha, P.R., and Fraunfelder, F. (2016): A Novel Gene Transfer Approach to Treat Fuchs’ Endothelial Corneal Dystrophy. Gordon Research Conferences, Feb 27-28, Ventura, CA.
  • Raikwar, S.P. and Zavazava, N. (2009): In vivo differentiation of Pdx1+CXCR4+ definitive endodermal cells into insulin producing cells efficiently correct hyperglycemia in diabetic mice. American Transplant Congress, May 30-June 3, Boston, MA. (Young Investigator Award and Invited First Plenary Speaker).
  • Raikwar, S.P. and Zavazava, N. (2009): Pdx1 promotes differentiation of embryonic stem cells into insulin producing cells. Experimental Biology 2009, April 18-22, New Orleans, LA (American Association of Anatomists: Stem Cells & Regenerative Medicine: Invited Speaker).
  • Raikwar, S.P. and Zavazava, N. (2007): Maximizing De Novo Insulin Secretion in Insulin Producing Cells Newly Derived from ES Cells Using TAT-Pdx1 and Pax4 Transcription Factors. American Transplant Congress, May 5-9, San Francisco, CA (Young Investigator Award).
  • Raikwar, S.P. and Zavazava, N. (2006): Real-time in vivo bioluminescence imaging for monitoring insulin-producing cells derived from embryonic stem cells. World Transplant Congress, July 22-27, Boston, MA (Young Investigator Award).
  • Raikwar, S.P. and Zavazava, N. (2006): Real-time in vivo imaging of insulin producing cells derived from embryonic stem cells. 4th annual meeting of the International Society for Stem Cell Research, June 29-July1, Toronto, Canada (ISSCR Travel Award).