Academic Information
Chair of Medical Pharmacology and Physiology
Bolm Distinguished Professor
George L. and Melna A. Bolm Distinguished Chair in Cardiovascular Health
Office
One Hospital Drive
Columbia, MO 65212
United States
P. 573-882-8260
Research Interests
- Regulation of muscle contraction
- Cardiac contractility
- Heart failure
- Exercise physiology
Areas of Expertise
- Muscle physiology
- Cardiovascular physiology
- Permeabilized muscle cell mechanics
- Single cardiac myocyte methodologies
- Working heart preparations
- Calcium imaging
- Muscle protein chemistry
- Gel electrophoresis and western blots
Education & Training
Post-Graduate School
PhD, Marquette University
Awards & Honors
- Research supported by NIH and AHA since 1997
- American Physiological Society, Cardiovascular Section, Fellow
- Served on NIH Cardiac Contractility, Hypertrophy, and Failure study section from 2006-2014
- Dorsett L. Spurgeon MD Distinguished Medical Research Award
- American Physiological Society Lamport Award to Young
- Scientist in Cardiovascular Physiology
Publications
- Hanft, L.M., B.J. Biesiadecki, and K.S. McDonald. Length dependence of striated muscle force generation is controlled by phosphorylation of cTnI at serines 23/24. J. Physiol. (Lond).591:4535-4547, 2013.
- Hanft, L.M., M.L. Greaser, and K.S. McDonald. Titin-mediated control of cardiac myofibrillar function. Arch. Biochem. & Biophys. 552-553:83-91, 2014.
- Clay, S., T.L. Domeier, L.M. Hanft, K.S. McDonald, and Maike Krenz. Elevated calcium transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan Syndrome with Multiple Lentigines. Am. J. Physiol. (Heart. Circ. Physiol.) 308:H1086-H1095, 2015.
- Nance, M.E., J.T. Whitfield, A.K. Gibson, L.M. Hanft, K.S. Campbell, G.A, Meininger, K.S. McDonald, S.S. Segal, and T.L. Domeier. Attenuated sarcomere lengthening of the aged murine left ventricle observed using two-photon fluorescence microscopy. Am. J. Physiol. (Heart. Circ. Physiol.) 309:H918-925, 2015.
- Hanft, L.M., T.D. Cornell, C.A. McDonald, M.J. Rovetto, C.A. Emter and K.S. McDonald. Molecule specific effects of PKA-mediated phosphorylation on rat isolated heart and cardiac myofibrillar function. Arch. Biochem. & Biophys. 601:22-31; 2016.
- Hiemstra, J.A., D.I. Lee, K. Chakir, M. Gutierrez-Aguilar, K.D. Marshall, P.J. Zgoda, N. Cruz Rivera, D.G. Dozier, B.S. Ferguson, D.M. Heublein, J.C. Burnett, C. Scherf, J.R. Ivey, G. Minervini, K.S. McDonald, C.P. Baines, M. Krenz, T.L. Domeier, and C.A. Emter. Saxagliptin and tadalafil differentially alter left ventricular structure and function in aortic-banded mini-swine. J. Am. Heart Assoc. 5:e003277; 2016.
- Hanft, L.M., C.S. Emter, and K.S. McDonald. Cardiac myofibrillar contractile properties during the progression from hypertension to decompensated heart failure. Am. J. Physiol. (Heart Circ. Physiol.). 2017.